Abstract
The aim of the study was to study the function of the fetoplacental complex in the dynamics of gestation in pregnant women living in a region of natural iodine deficiency and having insufficient iodine supply in the first trimester of gestation.Material and methods. A comprehensive study of the hormonal function of the fetoplacental complex in the second and third trimesters of gestation in 111 pregnant women was conducted. Group I consisted of 53 pregnant women with iodine deficiency in the first trimester of gestation. Group II included 58 pregnant women who had a normal level of iodine supply throughout the gestation period.The results of discussion. At 28-30 weeks of gestation, the progesterone level in group I was (p<0.05) 21.9% lower compared to group II, amounting to 356.1±2.6 nmol/l. Increasing to 35-36 weeks of gestation, the progesterone level remains lower in comparison with group II by 10.4%, amounting to 591.5±3.0 nmol/l. The level of placental lactogen at 28-30 weeks of gestation in group I exceeded its level in group II by 4.7% and amounted to 250.2±3.23 nmol/L, p<0.05. By the end of gestation in group I, its level decreased by 12.7% in comparison with the second trimester to 218.4±8.6 mol/l, which was 23.7% less in comparison with group II, p<0.05. At 28-30 weeks of gestation, the level of estriol in group I, amounting to 97.0±2.18 nmol/l, was 12.8% more in comparison with group II, and by 35-36 weeks, it increased to 99.9±2.45 nmol/l, which was 14.6% less in comparison with group II, p<0.05. The level of cortisol at 28-30 weeks of gestation in group I was 41,2% lower than its level in group II, amounting to 370.8±32.5 nmol/L, p<0,05. By the end of gestation, its level increased (p<0.05), but was 4.9% lower compared to group II, amounting to 692.2±22.38 nmol/l.Conclusions. The presence of fetoplacental complex dysfunction in pregnant women with initial iodine deficiency in the second and third trimesters of gestation, manifested by a multidirectional change in the level of its hormones in comparison with pregnant women who have a normal level of iodine consumption throughout gestation, was established.
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