Abstract
It has been noted by some investigators that lead is present in human parotid saliva, but there are no data on lead concentrations in parotid saliva of lead-exposed workers.This report describes the changes caused by Ca-EDTA administration and lead concentrations in parotid saliva of lead-exposed workers.The results were as follows:1) The distribution of lead concentrations in parotid saliva of lead-exposed workers was approximately logarithmic-normal.2) The geometric mean of lead concentrations in parotid saliva of lead-exposed workers was 0.617 μg/dl.3) Significant correlation was observed between the lead in plasma and parotid saliva (r=0.628) and the lead in blood and parotid saliva. The mean ratio of the lead concentrations in simultaneously obtained parotid saliva to plasma was 0.792.4) Lead concentrations in parotid saliva reached a maximum at 1 to 3 hours after Ca-EDTA administration and the rate of increase was 70-80%.5) Lead in parotid saliva had a molecular weight of approximately 15, 000, and it seems possible that lead binds to salivary proteins.
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