Abstract
Objectives : Herba on lipid levels in serum and lipid accumulation in liver tissue in high fat diet-induced hyperlipidemic mice. Methods : Experimental groups were subdivided into four; Normal diet group (Nor), Hyperlipidemic mice (Con), Lysimachiae Herba water extract administered mice (LWE), Lysimachiae Herba methanol extract administered mice (LME). Thereafter the changes in body weight, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. In addition histopathological changes in liver tissue was also observed. Results : Body weight, AST and ALT were not affected by the administration of water or methanol extracts of Lysimachiae Herba. However, methanol extracts of Lysimachiae Herba down regulated the total cholesterol and triglyceride in high fat diet - induced hyperlipidemic mice. Conclusions : In this study, results of total cholesterol and triglyceride showed significant effect in LME compared with LWE, but other results didn’t. Therefore, it is necessary to have more study of Lysimachiae Herba to apply hyperlipidemia.
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