РОЛЬ ХОЛЕСТЕРОЛА И ЭСТРАДИОЛА В РАЗВИТИИ ПЛАЦЕНТАРНОЙ НЕДОСТАТОЧНОСТИ ПРИ ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИИ В ТРЕТЬЕМ ТРИМЕСТРЕ ГЕСТАЦИИ

Abstract

To assess the role of cholesterol and estradiol in the development of placental insufficiency under cytomegalovirus infection (CMVI) in the period of gestation, cholesterol and estradiol were studied in the peripheral blood of 35 pregnant women who had a reactivation of chronic CMVI (IgG antibody titer to CMV is 1:1600) in the third trimester of pregnancy (the main group). As a control the blood plasma of 35 healthy women of the same period of gestation and age as in the main group were studied. It was found out that the reactivation of chronic CMVI in the third trimester of gestation was followed by the decrease of concentration of cholesterol by 23% ( p<0.001), of estradiol by 65% (p<0.001) in comparison with the values of healthy women. To analyze the chosen values for assessment, the discriminant function was found. It had the probability of differences not less than 95%; which that the discriminant equation was derived which for this study had the following formula: D=(-379×total cholesterol)+(-0.072×estradiol), where D is a discriminant function whose limit value is (-2673.59). If D is equal or less than the limit value, then the development of placental insufficiency in women in the third trimester of pregnancy is predicted, and if D is more than the limit value, then the normal course of the third trimester of pregnancy is predicted. Thus, the obtained results allow to establish the main role of disturbances of total cholesterol contents and key steroid hormone of pregnancy (estradiol) in the pathogenesis of placental insufficiency development under CMVI during gestation, which can be the basis for improvement of diagnostic and medical basis under this pathology of pregnant women.