Abstract
Many kinds of membranes are widely used for medical device. This review focuses on blood glucose meter (MEDISAFE®), leukocyte removal filters (IMUGARD®, IMUFLEX®), vitamin E-modified dialyzer (CLIRANCE®-E, CLIRANCE®-EE, CLIRANCE®-PSE) and cell therapy device.Current blood glucose meter (MEDISAFE®) is convenience, because patients only put a blood droplet on test strip, and need not to wipe blood. Porous polysulfone-type membrane was used for test strip, which removed blood cells from whole blood and was penetrated by plasma. Two types of latest blood glucose meters are averable, one inform the rebel of blood glucose on voice for blind patients (MEDISAFE VOICE®), and another need only one operation, that puncture, collect blood, and measure blood glucose (MEDISAFE® ez). Porous polysulfone-type membrane was also used for them.Leukocyte contamination in blood products have been shown to cause post-transfusion adverse effects. To eliminatethose effects, leukocyte number in products has been recommended to be less than 1-5×106/bag, then, we have developed leukocyte removal filters, IMUGARD® and IMUFLEX®, which are made of porous polyurethane membrane. The mechanism of leukocyte reduction with porous membrane was studied using polyurethane membrane, and followings were found. Leukocytes are removed at a constant ratio against thickness of porous membrane.There have been various reports on the effects of the vitamin-E modified dialyzer CLIRANCE®-E/EE. These effects include a decrease oxidative stress and oxidative products. Therefore vitamin-E modified dialyzers are expected to reduce prolonged complications.We have been developing a new filter device for MNC (mononuclear cell) separation using porous polyurethane membrane. This filter device has a transformable mechanism of compression-nonloaded state of the polyurethane membrane so that facilitates the object cell recovery from captured site. This filter shows over 90% of MNC recovery with over 95% of RBC (red blood cell), and about 90% of platelet removal from whole blood. This filter will be useful device for cell processing aim at the medical practices, such as cell therapy and reengineering therapy.
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