Abstract
Anticonvulsant drugs of the heterocyclic amide family in vitro inhibit enzymatic activity of Ca2+, Mg2+-ATPase of capsarcoplasmic reticulum, the activated transmembrane calcium ion transfer/ATP hydrolysis specific rate ratio being retained to provide lower concentrations of calcium ions in myofibrilla and relaxed muscles. Ethosuccimide is a noncompetitive inhibitor with reversible action on basic enzyme catalyzed processes. The inhibition of the hydrolytic activity of enzyme under the action of ethosuccimide, phenytoine and primidone was compared to their effect on other phosphatases (cAMP phosphodiesterase and Na+, K+-dependent ATPase)
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