Abstract
Summary. Background. A pathological increasing of coagulation activity causes disorders of blood rheological properties, that is a risk factor for large vessels thrombosis and coronary heart disease, myocardial infarction, thrombophilia and disseminated intravascular coagulation. Objectives: to study the effect of light desynchronosis on the functional activity of hemostasis coag- ulation mechanism in experiment. Materials/Methods. The experimental study was carried out on 36 nonlinear male white rats, divided into 3 groups: a control group that was not exposed to light desynchronosis, and 2 experimental groups under artificial lighting for 10 and 21 days, respectively. Coagulation hemostasis was assessed by following parameters: activated partial throm- boplastin time, prothrombin time, and fibrinogen content. Anticoagulant blood activity was assessed by antithrombin III activity. Plasma levels of soluble fibrin-monomeric complexes and D-dimers were used for fibrinolytic system assessment. The thrombin generation assay was used for thrombin activity assessment. Results. Light desynchronosis negatively impact hemostasis. On the 10th day of the experiment we revealed a compensatory increasing of anticoagulant and fibrinolytic activities. Exposure of experimental animals to prolonged light deprivation for 21 days caused stress development and hemostasis shift towards hyper- coagulation. Conclusions. Light desynchronosis leads to stress reaction in experimental animals as well as to hypercoagulable hemostasis disorders that creates the preconditions for thrombinemia.
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