電子密度・分子軌道制御に着目した反応中間体の設計と触媒反応への展開

Abstract

Activation of reactive intermediates using electron-acceptor moieties for increasing electrophilicity realized efficient transformations using organometallic reagents. The nucleophilic addition of organozinc reagents to electrophilic carbenoid intermediates derived from cyclopropenes generates allylmetal intermediates for subsequent allylation reactions of electrophiles. The control of neighboring boron atoms gives highly reactive intermediates for hydroboration and the Suzuki-Miyaura cross-coupling reaction. The design of multinuclear complexes provides excellent catalytic performances for the addition reaction of organozinc and organoaluminum reagents.