Abstract

A new method has been developed for determining nitrofuran derivatives (furazolidon, furadonin and furagin) in tablets and in urine, using an amperometric biosensor based on immobilized monoamine oxidase (MAO) and a printed platinum electrode. It is established that nitrofuran derivatives influence the catalytic activity of MAO like the classical tricyclic antidepressants (TCAs), but this effect is weaker than that of TCAs. The limits of detection for furazolidon, furadonin and furagin are 8.3 · 10 - 9, 8.5 · 10 - 8, and 9.4 · 10 - 10 mol/liter, respectively. The results show that the side effect of furazolidon, furadonin, furagin on the MAO activity must be taken into account by patients administering and doctors prescribing these drugs.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.