Изучение физико-химических свойств материалов на основе полимерных комплексов некоторых водорастворимых полимеров

Abstract

Polymer complexes based on water-soluble physiologically-neutral polymers are promising for creating biomedical materials used in targeted delivery systems of drugs, enzymes or genes, as well as for encapsulating biological substances in biomedicine. In this work, the creation of film materials based on polymer complexes has used the sodium salt of succinyl chitosan, polyvinylpyrrolidone, sodium salt of carboxymethylcellulose, polyethylene glycol. Polyvinylpyrrolidone and polyethylene glycol are characterized by unsatisfactory a film-forming and gel-forming property, which limits their application in medical practice. These shortcomings have been compensated by the introduction of polysaccharides. It has been shown that the variation in composition of the studied polymer complexes allows changing purposefully the hydrophilic-hydrophobic balance of the surface and sorption properties of polymer films based on them. The preparation of polymer complexes consisted of adding a portion of poly-N-vinylpyrrolidone or polyethylene glycol to solutions of the sodium salt of succinyl chitosan or sodium salt of carboxymethylcellulose so that the ratio of the components of the complex was equimolar. Films based on polymer complexes were prepared by the method of pouring solutions of polymer mixtures with a concentration of 1 mol/L onto a previously defatted surface of a Petri dish. The thickness of the film samples was maintained constant and equal to 0.1 mm. It was shown that the preparation of polymer complexes of the sodium salt of chitosan succinyl or the sodium salt of carboxymethyl cellulose with poly-(N-vinylpyrrolidone) or polyethylene glycol allows one to purposefully change the hydrophilic-hydrophobic balance of the surface of polymer films based on them. Also, film materials based on the studied polymer complexes have satisfactory sorption properties for water vapor. These facts suggest that systems based on polymer complexes of the sodium salt of chitosan succinyl or sodium salt of carboxymethylcellulose with poly (N-vinyl pyrrolidone) or polyethylene glycol can serve as the basis for the creation of film or gel polymer materials for medical use.