Abstract
Since the discovery of the cell in the 17th century, the life science has been developed by the contributions of many scientists. With the discovery of enzyme at the end of the 19th century, the chemical study of the creature has revealed the metabolic pathways in cells. And the double helix model of DNA proposed by Watson and Crick in the middle of the 20th century which gave a logical answer about the mystery of inheritance at molecular level. It established DNA as the design information of the proteins. On the other hand, it attracted attention to the role of biomembranes at the cell that is the basic unit of the life. I review where the study of biomembranes has reached in the 20th century, and also manifest the problems that have been left until the 21st century.
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