Abstract
The effects of vanadate (Na3VO4) on endocochlear DC potential (EP) and cochlear microphonics (CM) were studied at the basal turn of guinea pig cochlea and its distribution in the cochlea was observed with an electron probe microanalyzer (EPMA). The results obtained were as follows;1. With perfusion of vanadate solution from the scala tympani, EP showed a transient overshoot and then a gradual decrease.2. With the perfusion from scala vestibuli, EP showed a rapid decrease without an overshoot. The decrease of EP was time and dose dependent of vanadate perfusion.3. With anoxic anoxia, negative EP was recognized and its negative potential level was decreased by longer perfusion.4. Cochlear microphonic potentials showed a decrease in parallel with the decrease of EP.5. By the histolagical study with EPMA, abundant accumulation of vanadate was recognized at the stria vascularis and also at the Corti's organ.6. From the results obtained, it is concluded that vanadate inhibits the electrogenic pump at the stria vascularis and also inhibits the hair cells of Corti's organ.
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