Abstract
The effects of vanadate (Na3VO4) on endocochlear DC potential (EP) and cochlear microphonics (CM) were studied at the basal turn of guinea pig cochlea and its distribution in the cochlea was observed with an electron probe microanalyzer (EPMA). The results obtained were as follows;1. With perfusion of vanadate solution from the scala tympani, EP showed a transient overshoot and then a gradual decrease.2. With the perfusion from scala vestibuli, EP showed a rapid decrease without an overshoot. The decrease of EP was time and dose dependent of vanadate perfusion.3. With anoxic anoxia, negative EP was recognized and its negative potential level was decreased by longer perfusion.4. Cochlear microphonic potentials showed a decrease in parallel with the decrease of EP.5. By the histolagical study with EPMA, abundant accumulation of vanadate was recognized at the stria vascularis and also at the Corti's organ.6. From the results obtained, it is concluded that vanadate inhibits the electrogenic pump at the stria vascularis and also inhibits the hair cells of Corti's organ.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
