بررسی ارتباط سطوح سرمی آدیپونکتین با پروفایل لیپید، تستوسترون و کورتیزول در مردان کمتحرک

Abstract

Introduction: Adiponectin is one of adipocytokines secreted by adipose tissue that decreases with increased insulin resistance, dyslipidemia, obesity and diabetes. The purpose of this study was to investigate relationships between serum adiponectin levels and lipid profiles, testosterone, and cortisol in sedentary men. Methods: In semi-experimental study, forty five young men, without experience of regular physical activity during past six months were selected. After 12 h fasting (at 8 A.M.), Venous blood samples were collected for adiponectin, testosterone, cortisol and lipid profiles assessment. Moreover general characteristics of subjects were assessed. Data was analyzed using SPSS 16.0 software and the relationships were calculated by Pearson’s correlation analysis. Results: Adiponectin levels were negatively correlated to LDL cholesterol (r=-0.25, P=0.008), triglyceride (r=-0.30, P=0.003), and testosterone levels (r =-0.41, P=0.002) and positively correlated to HDL cholesterol levels (r= 0.26, P=0.005). No significant correlations were observed between adiponectin levels with total cholesterol (r= -0.21, P=0.053) and cortisol levels (r=0.16, P=0.089). Conclusion: It seems that in sedentary men, lower adiponectin levels are associated with dyslipidemia and consequently increased risk of metabolic syndrome and cardiovascular diseases in these subjects. Moreover, serum concentrations of adiponectin are directly correlated with testosterone levels, but it appears that there is no correlation between adiponectin levels and cortisol concentrations.