Abstract
The bioavailability of theophylline following administration of an experimental sustained-release preparation, Slo-bid Gyrocaps, was studied in four healthy subjects by measuring the salivary theophylline concentrations. Slo-bid and previously studied theophylline preparations (Theo-Dur ®, Theona-P ® and E-0686 granules, an investiga-tional drug) were not significantly different in AUC0-∞, MRT (mean residence time), tmax, or Cmax.The absorption of theophylline from Slo-bid was also studied in six healthy subjects under overnight fasting and non-fasting conditions. Higher concentrations were observed at an early absorption phase under the fasting condition than the non-fasting condition, but the extent of absorption of theophylline was not affected by food.
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