수산폐기물인 미더덕껍질 용매 추출물의 항산화 및 항고혈압 활성

Abstract

Styela clava tunic is generated in large amounts as a waste from S. clava processing plants and leads to environmental problems. It destroys the beach scenery and causes a bad smell and pollution by trashing on the seashore. Therefore, purpose of this study was to investigate antioxidant and antihypertensive activities of different solvent extracts from S. clava tunic for recycling of fishery waste. Antioxidant and antihypertensive activities of all extracts were concentration-dependent. Of extracts, hot water extract showed the highest DPPH radical scavenging activity with the lowest effective concentration (<TEX>$EC_{50}$</TEX>) value (0.733 mg/ml). Chloroform extract exhibited the highest metal chelation activity with the lowest <TEX>$EC_{50}$</TEX> value (2.696 mg/ml). Autoclaved water extract showed the highest NO radical scavenging activity with the lowest <TEX>$EC_{50}$</TEX> value (0.491 mg/ml) and n-hexane extract showed the highest reducing power (<TEX>$A_{700}=1.897$</TEX> at 100 mg/ml). And n-butanol extract showed the highest SOD-like activity with the lowest <TEX>$EC_{50}$</TEX> value (19.116 mg/ml) and ACE inhibition activity with the lowest inhibitory concentration(<TEX>$IC_{50}$</TEX>) value (0.149 mg/ml). These results indicate that extracts obtained from S. clava tunic may potential candidate to reduce diseases caused by various oxidative stresses and hypertension.