Abstract
The rapid development of technology has a significant impact on the daily life of a person. Light, sound, information pollution leads to sleep disturbance, which has a negative impact on the physical condition. Even short-term sleep disturbance caused by dark deprivation leads to a decrease in serum testosterone levels. The imbalance of male sex hormones, the synthesis of which is under the control of the hypothalamic-pituitary system, negatively affects the morphofunctional state of the testes. The effect of exogenous melatonin on the morphological and functional state of the spermatogenic epithelium of the testes, Leydig cells in white outbred male rats of 4 months of age was studied on the model of premature aging caused by 30-day dark deprivation, and the Klotho protein level in blood serum was assessed by enzyme immunoassay. It was found that the morphological changes in the testes were characterized by a decrease in the thickness of the spermatogenic epithelium by 30 days after darkdeprivation and a decrease in the level of the Klotho protein, which is a marker of premature aging. The introduction of exogenous melatonin had a protective effect on the morphological and functional status of the testes of animals, accompanied by the restorationof the spermatogenic epithelium, an increase in the Klotho protein to the level of thenegative control group
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