Abstract
Biosynthetic means using 13C labeled precursors were applied to the structure elucidation of new polyketide antibiotics which have been discovered in our laboratory. It was demonstrated that intra- and intermolecular 13C-13C couplings in 13C NMR spectrum of antibiotics highly enriched with 13C precursors afforded useful informations for structure elucidation. Microbial transformation of macrolide antibiotics under the presence of a polyketide biosynthetic inhibitor, cerulenin, led to the production of new “hybrid” macrolides. Further, production of the new hybrid antibiotic mederrhodins by a genetically engineered strain of Streptomyces is described.
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