Abstract
A gas chromatography-mass spectrometric method was employed for the determination of the antispasmodic drug, eperisone, in plasma. Excellent sensitivity was achieved by the selection of the base ion peak at m/z 98 of eperisone and a suitable internal standard, tolperisone, and by using a cyanopropylphenyl-bonded fused-silica capillary column. The lower limit of sensitivity was 10 pg/ml with a signal-to-noise ratio of 3. Another internal standard, decadeuterium labelled eperisone, was inferior to tolperisone in terms of accuracy and reproducibility at low levels of eperisone. The present method allows the determination of eperisone in human plasma after an oral administration of eperisone hydrochloride.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
