Abstract
Aim: to assess the efficacy of antiviral therapy in the treatment of acute respiratory viral infections in children in the context of contemporary clinical practice Patients and Methods: the study employed a pharmacoepidemiologic approach, utilizing a questionnaire survey of physicians to collect data on 6,116 children aged 3 to 7 years with mild to moderate acute respiratory infections. The study group included 5,144 (84%) children who received inosine pranobex. Comparison group 1 included 654 (11%) children who received other antivirals or immunomodulators. Comparison group 2 included 318 (5%) children who did not receive any etiological therapy. The clinical manifestations of acute respiratory viral infections, their duration, disease duration, complications, therapy, and the rationale for the choice of medications by the physician were analyzed. Results: disease duration in the study group (5.97±1.57 days) was significantly lower than in comparison group 1 (6.82±1.84 days, p<0.001) and comparison group 2 (6.79±1.88 days, p<0.001). Persistent complaints during convalescence were observed in 288 (5.6%) children in the study group, 154 (23.5%) children in comparison group 1, and 61 (19.2%) children in comparison group 2. Complications were reported in 164 (3.2%) children of the study group (n=169), 104 children (n=107, 15.9%; p<0.0001) in the comparison group 1, and 34 (n=34, 10.7%; p<0.0001) children of the comparison group 2. Conclusion: inosine pranobex has been demonstrated to reduce the rate of complications, prolonged cough, runny nose, and sore throat during convalescence, as well as overall disease duration, duration of the febrile period, and catarrhal phenomena in acute respiratory viral infections in children KEYWORDS: acute respiratory viral infections, COVID-19, herpesvirus infections, inosine pranobex, nasopharyngitis, acute tonsillitis, tonsillopharyngitis, real clinical practice, children. FOR CITATION: Ruzhentsova T.A., Garbuzov A.A., Meshkova N.A., Popova R.V., Slyusar O.I. Effect of antiviral therapy on the course of acute respiratory viral infections in children in contemporary conditions. Russian Journal of Woman and Child Health. 2024;7(2):163–170 (in Russ.). DOI: 10.32364/2618-8430-2024-7-2-12.
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