Abstract
Anti-DNA antibodies were released in the culture supernatant of spleen cells from BALB/c and autoimmune NZB/W F1 mice by the addition of LPS. The authors investigated the effect of several immunomodulators and immunosuppressants on the in vitro production of anti-DNA antibody. It was demonstrated that the anti-DNA antibody production in both mouse strain was not reduced by levamisole (LMS), bucillamine (SA96), and lobenzarit disodium (CCA), all which augmented the in vitro anti-SRBC PFC response. On the contrary, mizoribine, salazosulfapyridine (SASP), and platonin (NK-19) inhibited both anti-DNA antibody production and anti-SRBC PFC response. Mizoribine and SASP reduced the viability of cultured splenocytes, but NK-19 didn't. The results shows that every anti-rheumatic drug tested had a diffent action on the anti-DNA antibody production, suggesting the importance of further studies for their clinical application.
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