Свойства и безопасность комбинированной биологически активной добавки Уронекст в комплексном лечении острого (обострение хронического) цистита у женщин с бактериальным вагинозом

Abstract

Aim. To analyze modern approaches to the conservative therapy of acute (exacerbation of chronic) cystitis in women in combination with bacterial vaginosis. To emphasize the importance of Esherichia coli as the main causative agent of urinary tract infection (UTI) due to the presence of virulence factors that not only affect the affinity of the pathogen to the urothelium, but also hinder the development of an immune response. To emphasize the importance of bacterial vaginosis as a factor contributing to the development and maintenance of acute cystitis in women. To substantiate the need for a differential approach to the appointment of antimicrobial drugs in patients with UTI and bacterial vaginosis, as well as the use of safe natural medicines in the complex therapy of UTI. Materials and methods. The properties and safety of the biologically active additive Uronext (NPO Petrovax Pharm, LLC, Russia) were studied in women with complex, together with medications, treatment of acute (exacerbations of chronic) cystitis against the background of bacterial vaginosis. A post-marketing comparative study was conducted in parallel groups. The study lasted for 4 months and included 60 patients aged 18 to 65 years (average age 39.4 years). Results. The severity of differential symptoms of acute cystitis was significantly lower in the study group compared with the control group – the frequency of the evaluation mode in the study group was significantly higher than in the control group: 29 and 22 respectively (p<0.01). In both groups, there was a significant improvement in the quality of life of patients (ACSS score) after treatment (the median value and the mode of the sum of points in the control group decreased from 7 to 3; p<0.01, in the study group – from 7 to 1; p<0.01). The quality of life of patients in the study group after treatment was significantly higher than in the control group (p<0.01). It is important to note that the frequency of relapses after treatment was significantly lower in the study group compared to the control group (31.6 and 13.3% respectively; p<0.01). Conclusion. Modern dietary supplements as part of the complex therapy of lower urinary tract infection provide a significant reduction in the severity of differentiated symptoms of acute cystitis, as well as a significant improvement in the quality of life of patients.