Abstract
The effect of nephrectomy on the SHR rat superior mesenteric artery (SMA) and internal carotid artery (ICA) segments constriction and dilatation ability was studied under isometric conditions using myograph. 5/6 nephrectomy (5/6 Nx) in the rats 3 months old was used as a model of the chronic kidney disease. Dilatation of the phenylephrine-precontracted segments was induced by acetylcholine (AСh) or sodium nitroprusside (SNP) in the absence and presence of potassium channels blockers (tetraethylammonium, glibenclamide) or methylene blue, a guanylyl-cyclase inhibitor. The phenylephrine-induced contraction was slightly reduced in the SMA from 5/6 Nx rats relative to the control ones and significantly decreased in the presence of methylene blue. This reaction in the ICA from 5/6 Nx rats was significantly less than in the control ones, both in the absence and in the presence of the blockers and the inhibitor. The effect of nephrectomy on the dilatatory reaction of both arteries caused by AСh or SNP was not found, but the constrictor reaction of ICA to AСh in the presence of glibenclamide significantly decreased in 5/6 Nx, but not in control rats. We conclude that the chronic kidney disease may weaken endothelium dependent and independent vasoconstriction in the ICA from SHR rats, as well as differently change the signaling pathways of this reaction in different types of arteries.
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