Особливості кверцетину та його вплив на зміни у тканинах пародонта у дітей, які проживають в екологічно забруднених регіонах Прикарпаття

Abstract

Goal. Improving the effectiveness of treatment of patients with chronic catarrhal gingivitis living in ecologically favorable conditions and in ecologically polluted regions of Prykarpattia, by adding to the complex therapy of quercetin and chlorhexidine dent. The results of research by a number of scientists indicate that the use of quercetin in complex therapy helps to restore the antioxidant system, improve oxygen uptake by tissues and peripheral circulation, improve the rheological properties of the patient's blood. These properties of the drug were used by us in research. Research methods. We studied changes in periodontal tissues in children living in ecologically favorable conditions and in ecologically polluted regions of Prykarpattia, conducted a comparative description of periodontal changes and proposed a treatment plan for patients with chronic catarrhal gingivitis supplemented with chlorhexidine dent and quercetin. We examined 60 children with chronic catarrhal gingivitis living in the contaminated areas of Prykarpattia (Burshtyn) and 15 people with intact periodontium living in environmentally stable conditions. All patients underwent a full range of therapeutic measures, taking into account the removal of dental plaque and rehabilitation of the oral cavity. In 1 group of patients (30 people) patients were treated with chlorhexidine, calendula and chamomile infusion and 1 % mefenamine paste. Patients of group 2 (30 people) – the drug quercetin on the mucous membrane of the gums under the individual gingival cap and chlorhexidine dent in the form of oral baths. For the purpose of comparative characterization of the two groups, an index assessment of the condition of periodontal tissues and a study of rheographic parameters of periodontal tissues were performed. Scientific novelty. At the present stage used drugs chlorhexidine dent 0.12 % and quercetin for the treatment of periodontal diseases in children living in environmentally unfavorable conditions, studied the state of hemodynamics in periodontal tissues, studied rheographic parameters and their dynamics under the influence of treatment and prevention complex in children with chronic catarrhal gingivitis and evaluated the effectiveness of the developed treatment and prevention complex in children with chronic catarrhal gingivitis living in environmentally unfavorable conditions. Conclusion. The results of the study did not show a significant difference between clinical and laboratory parameters in patients 1 and 2 groups before treatment (p > 0.05), but they differed significantly from those in the comparison group (p < 0.05), which points out that unfavorable environmental living conditions have an impact on the course of periodontal disease in children. We found a significant difference in the blood supply to periodontal tissues in patients with chronic catarrhal gingivitis compared with (p < 0.05). The results of the study showed that the use of quercetin and 0.12 % chlorhexidine solution in the complex treatment of patients with chronic catarrhal gingivitis provided a significant improvement in clinical and laboratory characteristics of periodontal tissues in children living in different environmental conditions, and stabilized these indicators in long-term observation.The use of the proposed treatment regimen for patients with chronic catarrhal gingivitis stimulates metabolic processes in periodontal tissues, reduces cyanosis, edema of periodontal tissues according to the results of rheography of periodontal tissues. After treatment, we observe the normalization of the rheological characteristics of the gums, which indicates an improvement in blood circulation in periodontal tissues in these patients (normalization of qualitative and quantitative characteristics of rheograms). Key words: chronic catarrhal gingivitis, ecologically polluted areas, chlorhexidine, quercetin, reorganic changes of periodontium.