Abstract
Identification of the tumor cell immunophenotype in acute lymphoblastic leukemia (ALL) by flow cytometry is one of the priority diagnostic methods, determining the correct choice of therapy. The flow cytometry immunophenotyping standards are still not determined in Russian Federation - at the national level or at the levels of individual study groups. The groups involved in the ALL-MB-2015 study have created a reference center intended for repair of the flaws of flow cytometry immunophenotyping in the clinics involved in the study. The work of the reference center has made it possible to identify numerous problems with flow cytometer calibration, wrong choice of monoclonal antibodies and preparation of samples, incorrect analysis and interpretation of flow cytometry data. These results demonstrate very serious problems in flow cytometry immunophenotyping in Russia and complete absence of standards for this method. The basic solution for this problem is potential centralization of flow cytometry immunophenotyping at several major laboratories with experienced staff.
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