遷移金属錯体触媒を用いる炭素‐炭素結合の選択的切断反応 β‐炭素脱離反応を中心に

Abstract

The development of efficient methods for the selective cleavage of carbon-carbon bonds catalyzed by transition metal complexes is a central and challenging subject of modern organic synthesis. Alkene insertion into metal-alkyl bonds has been recognized as a fundamental step in many catalytic reactions. The reverse reaction, i.e., carbon-carbon bond cleavage via β-carbon elimination, has recently received growing attention. Since Watson and Roe reported the first example of β-methyl elimination of (C5Me5) 2LuCH2CH (CH3) 2, several examples of reversible β-alkyl insertion-elimination at both early and late transition metal centers have been reported. Recently, the reactions which involve catalytic carbon-carbon bond cleavage via β-alkyl elimination are in progress. Here, both stoichiometric and catalytic carbon-carbon bond cleavages via β-alkyl elimination as a key step of the reaction are summarized from the synthetic, industrial and environmental point of view.