Abstract
(-)-Hydroxycitric acid (HCA) is the principal acid Garcinia cambogia fruit rind and has been shown a potent inhibitor of ATP-citrate lyase (EC4.1.3.8) and thus frequently used for weight control. Examination was made of the effects of jelly drink containing Garcinia cambogia extract and partially hydrolized guar gum on obesity in human subjects not yet obese (body mass index, 25 to 30 kg/m2). One pack (200g) of jelly drink was provided to each of 16 adult volunteers (41.3 ± 8.0 years old, 6 males, 10 females) containing 250 mg HCA three times a day, meal time, for 12 weeks. Serum mineral content was measured and hemological and hemobiological date were obtained at 4-week intervals throughout the test period and also during a 2-week post treatment period (14 weeks). Energy and mineral intake from food and drink were recorded and evaluated by a dietician. Tomography (CT) scans were obtained for each subject at the umbilical level before and after treatment. Body weight, BMI, body fat ratio, waist circumference and hip circumference all indicated, significant reduction after treatment. Total fat area (TFA) and Visceral fat area (VFA) were noted to have decreased significantly (p < 0.05). No toxicological change could be detected during the 14-week period. The regular use of jelly drink containing Garcinia cambogia extracts and partially hydrolyzed guar gum is thus shown by the present findings to be a safe effective means for reducing body weight, BMI, body fat ratio, waist circumference, hip circumference, TFA and VFA in persons prior to becoming obese. It’s daily use may thus be recommended for body weight control.
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