Алгоритм диференційованого вибору лікарських засобів при терапії гострого простого бронхіту у дітей

Abstract

Purpose — to develop and study the effectiveness of the author's algorithm of differential choice as regards medicines in the inpatient therapy for acute bronchitis in children. Patients and methods. On the basis of correlation analysis and sequential Wald's analysis, the algorithm of differential choice of medicines (recombinant interferon alpha-2β; probiotical agent Bacillus subtilis; bacterial lysates OM-85; Ivy extract) which are to be used in management of children with acute simple bronchitis (ASB) was developed. The differential administration of medicines for management of ASB in children was shown to lead to the faster resolution of catarrhal and inflammatory syndromes, as well as contribute to the restoration of non-specific immunity indicators. The results of introduction of the algorithm of doctor's actions into healthcare practice have demonstrated that the estimated effectiveness of usage and likelihood of acquiring the final result are equal to 75–86%. Conclusions. Features of functioning of the system of non-specific respiratory tract defense in children of 1 to 6 years old with ASB, their clinical and anamnestic characteristics, as well as dynamics of ASB course according to BSS justify the necessity to reinforce standard inpatient therapy of ASB. The administration of recombinant interferon, probiotical agents, bacterial lysates and Ivy extract for children of 1to 6 years old with ASB in order to restore non-specific immunity was pathogenetically justified based on proved clinical and immunologic effectiveness along with their influence on major clinical signs of acute bronchitis according to Bronchitis severity score (BSS).