Abstract

Eight healthy adults were examined electro-nystagmographically to evaluate the influence of sodium amobarbital on the human vestibular system. Seven of them showed direction-changing positional nystagmus with the direction toward the lower ear in six, and toward the upper ear in one. There was no difference of mean slow phase velocity between right and left positional nystagmus. Downbeat nystagmus, horizontal and vertical gaze nystagmus, and saccadic pursuit were also observed in the supine position. We concluded that direction-changing positional nystagmus after a I.V. injection of sodium amobarbital is due mainly to its action on the central vestibular system.

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