Abstract
Objective. To evaluate the accuracy and informativeness of two endoscopic indices for ulcerative colitis (UC) activity recommended for pediatric practice (Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and Mayo ES) and analyze their correlation with clinical and laboratory indicators of disease activity. Patients and methods. This study included 80 patients (42 boys, 38 girls) aged 5 to 18 years diagnosed with UC. The activity of UC was evaluated using the Pediatric Ulcerative Colitis Activity Index (PUCAI). Laboratory examination included measurement of hemoglobin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fecal calprotectin. All children underwent ileocolonoscopy with the assessment of endoscopic severity using the UCEIS and Mayo ES. Results. We identified a significant correlation between UCEIS and Mayo ES (Spearman ρ 0.771, p < 0.001). Both endoscopic indices also correlated with PUCAI (Spearman ρ 0.660, p < 0.001 and Spearman ρ 0.625, p < 0.001, respectively). The level of fecal calprotectin demonstrated the highest correlation with UCEIS and Mayo ES (Spearman ρ 0.594 and 0.595, p < 0.001, respectively). Conclusion. The UCEIS and Mayo ES are highly accurate and informative for the assessment of UC inflammatory activity in children. The UCEIS scale is more detailed, while Mayo ES scale is easier to use in clinical practice. Key words: ulcerative colitis, colonoscopy, endoscopic activity indices, UCEIS, Mayo ES.
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