Abstract
Endolymphatic hydrops were tried to produce in 33 guinea pigs by obliteration of the endolymphatic sac, and the following three points were investigated.1) The incidence of the spontaneous nystagmus.2) The relationship between the time course and the degree of endolymphatic hydrops.3) The relationship between the caloric response to cold water stimuli and the degree of endolymphatic hydrops.The results were as follows:1) By this procedure, endolymphatic hydrops were produced in 24 out of 33 guinea pigs (72.7%). The spontaneous nystagmus was noticed in 3 cases. However these spontaneous nystagmus seemed to be originated from other pathological changes. Namely, two cases were accompanied with labyrinthitis and one was labyrinthine bleeding.2) Endolymphatic hydrops were more remarkable in the postoperatively prolonged cases.3) The cases which showed severe endolymphatic hydrops had tendency of decreased caloric response to cold water stimuli.Although the spontaneous nystagmus was not noticed in these model animals, morphologically and functionally these results were very similar to the findings of the patients with Meniere's disease.
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