Abstract
This study aimed to evaluate and develop -coated pellets based on the dissolution using the paddle method. As coating materials, two types of were applied to obtain either sustained release form or fast released form. The dissolution test was carried out in phosphate buffer solution (pH 6.5) at , 100 rpm. In order to develop a sustained release preparation containing felodipine, a comparative dissolution study was done using commercial product as a control. The dissolution at 30 min of felodipine from RS or RL-coated pellets were 0.96% and 99.65, respectively. The weight ratio of RL pellets to RS pellets altered the dissolution rate, but did not optimize the dissolution rate. However, the sustained dissolution of felodipine from pellets was optimized by varying the coating ratios of RS. It is suggested that the coating ratio of pellets is the main factor which controls dissolution rate. Taken together, RS 30D-coated pellets showed the most comparable dissolution rate pattern to commercial product, . This sustained release pellets for oral delivery system of felodipine was simply manufactured, and drug release behavior was highly reproducible.
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