Донація ооцитів як метод лікування безплідності у поганих відповідачів у клініці допоміжних репродуктивних технологій

Abstract

The objective: сomparative characteristics of patients – poor responders and egg donors with the study of the effectiveness of corypholitropin-α in the schemes of controlled ovarian stimulation with GnRH antagonists protocols. Materials and methods. The analysis of the main clinical characteristics of the patients in the selected groups, age category, social status, level of education, structure of motivations for participation in ART programs, etc., was carried out. The effectiveness of the scheme of controlled ovarian stimulation using prolonged FSH in the protocol with antGNRH was analyzed in comparison with the daily injections of recombinant FSH into the controlled ovarian stimulation programs in egg donors. Results. A statistically significant difference was found in the age of the patients in the selected groups, differences in social status, level of education, etc. It has been proven that ovarian stimulation with corypholitropin-α is as effective as daily injection of recombinant FSH for controlled ovarian stimulation from egg donors. In addition, patient perception of protocols using сorifollitropina-α proves better tolerability compared to traditional protocols, due to fewer injections, which reduces the likelihood of early termination of treatment. Conclusion. The use of prolonged-action FSH has the same efficacy as the traditional protocols of controlled ovarian stimulation in terms of the number of oocytes and embryos obtained, as well as the frequency of pregnancy per cycle and transfer, but at the same time demonstrates a statistically lower dose of FSH. Key words: poor responders, egg donors, controlled ovarian stimulation, corypholitropin-α.