Abstract
Water-soluble polymer esters of oxacillin based on linear poly-N-(2-hydroxypropyl) methacrylamide (HPMA) and branched hemodegradable poly-HPMA containing interchain labile urethane bonds were synthesized and characterized by their composition, homogeneity, molecular weights (MW), and antimicrobial activity. Hydrolysis kinetics at 37°C of poly-ester oxacillin based on branched poly-HPMA with MW = 71000 in a physiological solution at pH 7.0 and in a buffer at pH 2.0 were investigated by the method of dialysis through cellophane membrane. It was established that under these conditions polymer ester of oxacillin is hydrolyzed at a high rate (in particular in an acid medium) determining the possibility of prolonging antimicrobial activity of oxacillin. All polymer esters of oxacillin thus obtained exhibit considerable antistaphylococcus activity.
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