Abstract
We investigated virus inactivation by two albumin products (Sekijyuji Albumin® and Sekijyuji Albumin 25® derived from human plasma with heat treatment at 60°C in liquid-phase (pasteurization) using several enveloped and non-enveloped viruses as marker viruses. Enveloped viruses were sindbis virus (SIN), vesicular stomatitis virus (VSV), herpes simplex virus type-1 (HSV-1) and human immunodeficiency virus type-1 (HIV-1). Non-enveloped viruses were polio virus (Polio V) and hepatitis A virus (HAV). The infectivity of all viruses except HAV was lost after 1hr heating, with logarithmic reduction value (LRV) for SIN, VSV, HSV-1, HIV-1 and Polio V of >5.1, >5.7, >4.3, >3.8 and >5.9, respectively. No significant difference in LRVs were observed between the two products. The infectivity of HAV, however, remained at 104.2-5.0 TCID50 even after 10hr heating and LRV stayed in the range of 1.9 to 2.7.
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