Abstract
Introduction. Solvents and diluents for parenteral medicines are widely used in pediatric hospitals and occupy leading positions in terms of the number of packages in purchases. Injectables are prescribed to children in reduced volumes, as compared to adults. In this regard, it is relevant to study the solvents and diluents available for parenteral administration of drugs in terms of packaging types and reduced volumes for use in pediatrics in the domestic pharmaceutical market. Aim of the study is to analyze the available solvents and diluents for parenteral medicines, such as water for injection, isotonic solutions of sodium chloride, Ringer, and Ringer lactate, on the Russian pharmaceutical market and in a multidisciplinary children’s hospital. Material and Methods. Objects of the study were data from the State Register of Medicines of Russia, the requisition slips of Medical Devices and Pharmacy of Tatarstan for medicines shipped from a warehouse to the Republic Clinical Children’s Hospital of the Ministry of Health of the Republic of Tatarstan in 2022, the price lists for medicines of pharmaceutical wholesalers (September 2023), and the data from scientific publications. Results and Discussion. The data obtained indicate that the regional pharmaceutical market has about twice as many options for the supply of medicinal solvents and diluents than in a children’s multidisciplinary hospital, and this allows expanding the range of this group of medicines. It can be assumed that pharmaceutical industrial enterprises do not produce a full range of options for the volume of primary packaging of solvents and diluents registered in the State Register of Medicines. Conclusions. In Russia, reduced volumes (20-30 ml) of 0.9% sodium chloride, 5% glucose, Ringer, and Ringer lactate solutions in vials for intravenous drip administration in pediatric practice are neither registered nor produced. The depth coefficient of the assortment of the studied solvents and diluents for parenteral medicines in relation to the volume of primary packaging in a children’s multidisciplinary hospital is 0.102. This indicates the need for medical organizations to consider the possibilities of the pharmaceutical market when drawing up applications for the supply of medicines.
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