ХИМИЧЕСКИЙ СОСТАВ И БИОЛОГИЧЕСКОЕ ДЕЙСТВИЕ ЭКСТРАКТА ИЗ ПЛОДОВ РЯБИНЫ

Abstract

The object of this study was the extract obtained from the dried pomace of rowanberry amurensis (Sorbus amurensis Koehne) after juice separation. It was studied the total polyphenols contents, lipids pattern and antiradical activity of the extract. The total polyphenols contents made 80±2,5 mg gallic acid equivalents per 100 ml, which specify the level of its antiradical activity that was determined at the level of 29,73±0,23 mmol equvalents of trolox per liter. Lipids constituent included 3 phospholipid and 6 neutral lipids fractions. Its contents was found within 13,4±0,14 mg of total lipids per ml. Findings indicate to the high biological activity of the extract and the reasonability of its experimental study. It was shown on the laboratory model of toxic carbon tetrachloride hepatitis in rats that extract from the rowanberry at endogastric administration in dosage of 100 mg of total polyphenols per kg of body weight, possess expressed antioxidant and hepatoprotective activity. Administration of the extract facilitate the decreasing of the general lipids contents, specific liver weight, alanine aminotransferase activity, as well the level of the reduced glutathione and activity antioxidant and lysosomal enzymes is normalized. Extract from rowanberry is a promising source for developing of biologically active food supplements with high antioxidant and antiradical activity.