銀系無機抗菌剤の歯科材料への応用 第１報 イオンピュア｀ＴＭ´の各種毒性試験

Abstract

Hitherto, many kinds of anti-bacterial reagents have been developed. Those anti-bacterial reagents could be divided into two groups such as organic and inorganic reagents. The silver-inorganic reagents have been interesting as a substitute for the organic reagent, since those inorganic reagents might resolve the problems of organic reagents such as the short-term durability of anti-bacterial effect, degeneration by proceeding or heating operation, and physical irritation. The purpose of this study was to investigate whether or not the silver-inorganic reagents could be applied biologically to dental materials. IonpureTMwas used as the silver-inorganic anti-bacterial reagent. Biological reactions of Ionpure were measured by the standard biological tests such as the toxic tests proposed by OECD and patch test by Kawai's method.The results were as follows1. In acute toxicity testing by oral ingestion of Ionpure, no mortality of mice was observed by the single dose of 5, 000 mg/kg. Lethal dose by oral ingestion of Ionpure was estimated to be more than 5, 000 mg/kg. The general condition, including the average weight, did not indicate abnormal signs during the experimental period. Furthermore, no pathological finding was observed in the internal organs by dissection after testing.2. In the dermal sensitization by modified Draize test, the eye irritation test, and the mutagenesis test, Ionpure was evaluated to be negative, whereas the evaluation of the patch test by Kawai's method was semi-negative.