Abstract
The influence of agihg an the hepatic metabolism of propranolol, i. e. conjuation, sidechain oxidaion and ring fxidation, was investigated in 32 inpatients aged 30 to 84 yr. Plasma propranolol concentaion and urinary main metabolites [propranolol glucuronide (PPLG), naphthoxylactic acid (NLA), and 4-hydroxypropranolol (4OHP) were measured after a single oral dose of 20mg propranolol. There were significant correlations between age and1) maximum propranolol concentration, 2) area unde the plasma concentration-time curve and 3) elimination half-life. Apparent oral clearance of propranolol was invesely correlated with age. Partial metabolic clearance (PMC) to 4OHP (ring oxidation) and PMC to NLA (side-chain oxidation) were significantly correlaed with age, while PMC to PPLG was not. In addition, the ratio of PMC to 4OHP to that of PMC to NLA was mot associated with age. These obserations suggest that there are age-related reductions in two oxidizing capacities, while there is no significant infuence of aging on the conugating capacity. The age-related reduction in oral clearance of propranolol may be Rainly caused by the decline in the capacity of two diffrent oxidation pathways.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
