小児じん疾患におけるＡｎｔｉｔｈｒｏｍｂｉｎ ＩＩＩの動態

Abstract

The level of antithrombin III (AT-III) and its relationship with histological changes were investigated in children with various renal diseases such as acute glomerulonephritis (AGN), persistent glomerulonephritis (PGN), purpura nephritis (PN) and nephrotic syndrome (NS).No discrepancy was observed between plasma AT-III levels assayed immunologically and biologically. In the acute phase of AGN, plasma AT-III level was decreased and urinary AT-III level was increased. In cases with PGN or PN, plasma and urinary AT-III levels were within normal limit level except the latter in cases with massive proteinuria. In the relapse phase of NS, AT-III level was markedly decreased in plasma and increased in urine.In cases with glomerulonephritis (AGN, PGN and PN), the increase of urinary AT-III was proportional to the severity of pathological changes in renal glomeruli. The glomerular deposition of AT-III was rarely observed in cases with marked fibrin deposition in renal glomeruli.Thus, the decrease of plasma AT-III level in acute or relapse phase of renal disease is possibly due to its leakage into urine. And in cases with glomerulonephritis, AT-III may play a vital role in the formation of fibrin deposition in glomeruli.