АКТУАЛЬНЫЕ ВОПРОСЫ ПРОФИЛАКТИКИ ПЕРИНАТАЛЬНОГО ВИРУСНОГО ГЕПАТИТА С

Abstract

Transplacental HCV-antibodies circulate in the blood of infants during the first year of the life and diagnosis of HCV-transmission is difficult. Aim: to study informativeness of serological diagnostic tests in anti/HCV-positive infants. Material and methods. the study was conducted in two groups of infants: RNA-positive (n=28) and RNA-negative (n=277). All children were born from a pregnant woman with chronic viral hepatitis C. The authors determined the sensitivity, specificity and accuracy of serological diagnostic tests for HCV transmission in infants: anti/HCV total, anti-HCcore IgG, anti-HCcore IgM, anti-HCNS3 IgG, anti-HCNS3 IgМ, anti-HCNS4 IgG, anti-HCNS4 IgМ, anti-HCNS5 IgG, anti-HCNS5 IgМ. Results. Detection of anti-HCV IgG-antibodies in the first 9 months of a child’s life has a high sensitivity but low specificity and low diagnostic efficacy; detection of anti HCV-IgM antibodies in the blood of the infant has significant specificity and high diagnostic efficacy. Discussion. The terms of examination of infants for viral hepatitis C are regulated by Sanitary Regulations and Standards (SanPiN 3.1.3112-13 Prevention of viral hepatitis C). We found that the detection of IgG antibodies in the blood of infants who were born to HCV-positive women has low diagnostic efficacy and will not lead to a correct diagnosis of perinatal HCV- transmission. It is necessary to develop and make changes in sanitary epidemiological rules. Conclusion. detection IgG-antibody is not informative during the first half of the infant’s life, but detection IgM-antibody is highly specific and accurate serological test for diagnostic HCV-transmission to child from mother with chronic viral hepatitis C.