Оценка эффективности и безопасности местного средства на основе аммония глицирризината при ветряной оспе у детей

Abstract

The search for new effective and safe medications for external therapy of varicella in children remains highly relevant. Objective. To evaluate the efficacy and safety of a topical gel containing ammonium glycyrrhizinate for the treatment of varicella in children. Patients and methods. This study included 32 patients with varicella aged between 4 and 9 years. Study participants were randomized into two groups: patients in the experimental group received topical therapy with ammonium glycyrrhizinate, whereas patients in the control group received topical therapy with a medicine containing calamine and zinc oxide. Results. Patients in the experimental group demonstrated faster recovery than in control group: they had shorter period of new rash, shorter duration of rash on the mucous membranes; on day 4, there was a significant decrease in the proportion of patients with local edema and hyperemia in the area of rash; there was also a reduction in itching during the entire observation period, while patients in the control group had worsening of itching on days 5 and 6; we observed a 2-day reduction in the duration of secondary bacterial infection of rash. In the experimental group, there was a decrease in the proportion of patients with fatigue and its duration (to 4 days), as well as faster restoration of appetite compared to control group. Conclusion. Our findings allow us to recommend the gel containing ammonium glycyrrhizinate for effective topical therapy of varicella in children. Key words: ammonium glycyrrhizinate, varicella, glycyrrhizic acid, children, topical therapy