Abstract
Aggressive behavior is an integral part of the human psyche. However, environmental risk factors, mental illness and somatic diseases can cause increased aggression, which represents the biological basis of antisocial behavior in a human society. An important role in the development of aggressive behavior belongs to the hereditary factors, that are probably related to abnormal functioning of neurotransmitter systems in the brain. However, the underlying genetic mechanisms remain unclear. The present study aimed to assess the main effects of monoaminergic systems gene polymorphisms (serotonergic - SLC6A4 , HTR2A , HTR1B, dopaminergic - DRD4 , MAOB ) together with haplotypic and gene-environmental effects on individual differences in aggression level in 642 mentally healthy individuals with sex and ethnicity inclusion as covariates. Aggression level was assessed using the Russian version of the Buss-Perry Aggression Questionnaire. The genotyping of the SLC6A4 ( 5-HTTLPR and rs1042173 ), HTR2A ( rs7322347 ), HTR1B ( rs13212041 ), DRD4 ( rs1800955 ), MAOB ( rs6651806 ) gene polymorphisms was conducted via polymerase chain reaction (real time and restriction fragment length polymorphism analysis). Statistical analysis included multiple linear/logistic regression (PLINK v. 1.9). The correction for multiple testing was conducted by the FDR procedure (False Discovery Rate). Statistical analysis revealed the association of SLC6A4 5-HTTLPR S -allele with an increased aggression level in men (pFDR = 0.022) and in Udmurts (pFDR = 0.009). In addition, we revealed that paternal care significantly affected association of SLC6A4 rs1042173 and aggression level (p = 0.001). The study demonstrated environmental, genderand ethnicity-specific role of the SLC6A4 gene in individual differences in aggression level in mentally healthy individuals.
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