同種脱灰骨，新鮮自家骨髄，ヒドロキシアパタイトか粒の単独および混合埋入に関する実験的研究 皮下ならびに顎骨欠損部への埋入

Abstract

The effect of implant of single or composite materials on the back subcutaneous tissue and jaw bone defect was studied experimentally in rabbits. The materials used were autogenous bone marrow (BM), hydroxylapatite particles (HA), allogenic demineralized bone (DB), BM+HA, BM+DB and HA H-DB. After implantation of these materials, histologic findings were studied at various intervals, with particular attention to new bone formation and its remodeling. The results were as follows:1. Subcutaneous implants: Ectopic ossification was induced in BM group, and the newly formed bone showed finally so-called ossicle. Bone formation was not seen in any HA group animals throughout the experimental period. Cartilage with ossification could be seen in and around DB fragments of DB group. Trabecular bone surrounding HA particles was formed in BM+HA group, but bone marrow-like spaces could not be found. Prominent bone and cartilage formations were induced in BM+DB group. In HA+DB group, multinucleate giant cells were observed in close contact with HA particles and DB fragments, however, no bone formation was seen in any animals.2. Implants in jaw bone defect: Prominent bone formation and its remodeling were seen in BM group, showing finally repaired jaw bone defect by cortical bone and trabecular bone. Trabecular bone surrounding HA particles was formed near the margin of the jaw bone defect in HA group, but its complete remodeling was not seen. Ossification with fibrous bone formation and cartilage formation were seen and the jaw bone defect was finally replaced with new bone in DB group. The jaw bone defect was filled with trabecular bone surrounding HA particles but bone marrow-like structure was not formed in BM+HA group. In BM+DB group, prominent bone formation and its remodeling were seen and the jaw bone defect was finally repaired by cortical bone and trabecular bone. The jaw bone defect was finally filled with trabecular bone surrounding HA particles in HAH-DB group, though the remodeling of jaw bone defect was slower somewhat than that in BM+HA or BM+DB group. The results of the present study suggest that composite implant materials consisting of DB and other substances such as BM or HA are most suitable for reconstrtlcting jaw bone defects.