Abstract
The effect of the intravenous infusion of prostaglandin E1 (PGE1) on the penlymphatic oxygen partial pressure (PcoO2) and systemic blood pressure (SBP) was studied in 6 guinea pigs. The polarographic method was used to measure PcoO2 by placing the microelectrode in the perilymph of the scala tympani through the fenestrated bony wall of the basal turn. PGE1 produced slight decreases in PcoO2 and SBP under control anesthetized conditions. The effects of aspirin and prostaglandin I2 (PGI2) on the CO2 response of PcoO2 was also measured in 21 anesthetized guinea pigs. Intravenous aspirin (300mg/kg) greatly inhibited the CO2 response of PcoO2, but it had no significant effect on SBP, arterial partial pressure of CO2 or arterial pH. This inhibition was partially reversed by the intravenous infusion of PGI2 (0.1μg/kg/min). These results support the suggestion that PGI2 participates in the chemical regulation of the cochleovascular circulation.
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