بررسی تأثير تمرین مقاومتی بر سطوح عامل نوروتروفیک مشتق از مغز در پلاسمای موشهای صحرایی

Abstract

Introduction: Brain ‐ derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family that plays key role in regulating survival, growth and maintenance of neurons. BDNF is thought to be contributed in thecellular and molecular responses to exercise; however, the effects of exercise interventions on BDNF are not well understood. Therefore, the purpose of this study was to examine the effect of resistance training on plasma BDNF levels in rats. Methods: Forty female Wistar rats were divided randomly into control and resistance training groups. The resistance-training group, consisting two subgroups, 4 weeks and one exercise session. Ladder climbing while carrying weights was considered as resistance training task. Each session contained three sets of training with five repetitions. In the group with one training session, immediately, 24, 48 and 72 hours after the exercise and in the group with 4 weeks training sessions, 24, 48 and 72 hours after the last exercise session, the animals were anesthetized and blood samples were taken. Results : The result showed that t here are signifiant difference in plasma BDNF levels between the one resistance exercise and 4 weeks resistance training groups at time course of 24h (P=0) , 48h (P=0.001) and 72 hours (P=0.002) . Plasma BDNF levels decreased following by 4 weeks resistance training at time course 24 and 72 h after the last exercise session (P=0.04 and 0.02 respectively). Plasma BDNF levels increased significantly in the test group following by a resistance exercise at time course immediately, 24 and 72 h after exercise(P=0.001, 0.009 and 0.027 respectively). Conclusion: Number of the training sessions has important role on plasma level of the neurotrophin in response to the resistance training . Thus, resistance exercise is one of the proper models to examine the molecular behavior of this neurotrophin .