Abstract
Immunization of rats with native bovine type II collagen results in a polyarthritis in approximately 90% of the rats. Using an enzyme-linked immunosorbent assay, IgG antibodies to type II collagen in serum and paw tissue were measured as total IgG and as its subclasses (IgG1, IgG2a, IgG2b, IgG2c) in arthritic and non-arthritic rats. Anticollagen IgG subclass analysis revealed that the major subclass was IgG2a in both the serum and paw extract, with minor amounts of IgG2b, IgG2c and IgG1. Serum levels of anticollagen IgG2a in arthritic rats were significantly higher than those of non-arthritic animals. The significance of these results and their possible relevance to human disease are discussed.
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