Показатели глобальной продольной деформации миокарда левого желудочка у молодых женщин с дисплазией соединительной ткани

Abstract

Diagnosis of undifferentiated connective tissue dysplasia (UCTD) is a complex and controversial problem in the clinic of internal diseases. The medical and social significance of UCTD in young women is due to the variability of symptoms and the progressive course with multiple organicity and polysystemic disease. In therapy and cardiology, attention is focused on the issues of timely diagnosis of heart failure (HF) in individuals with preserved left ventricular ejection fraction (LV EF). Expert-grade ultrasound scanners are used to identify preclinical signs of LV myocardial dysfunction and assess LV myocardial deformation. In young women with UCTD, the indicators of global longitudinal systolic LV deformation have not been specifically studied before. The purpose — to evaluate clinically the longitudinal deformation of the LV in young women with UCTD using speckle tracking echocardiography. Material and methods. Global longitudinal peak strain (GLPS_Avg) was assessed in 30 young women with UCTD (average age 24.2 (2.8) years). The control group included 32 practically healthy women, comparable in age (23.9 (2.4)) years without signs of UCTD. Results. The echographic parameters in both groups did not differ significantly (p>0.05) and were within the normative values. According to the GLPS_Avg assessment, it was found that the global longitudinal systolic LV deformation in the group of young women with UCTD was significantly lower than in the control group (p = 0.008). The results obtained may indicate a violation of the contraction and relaxation of the longitudinal fibers of the myocardium in young women with UCTD. Conclusion. It can be assumed that a reliable indicator of global longitudinal systolic LV deformation (GLPS_Avg) is explained by the presence in young women with UCTD of a defect in the connective tissue framework of the heart, which serves as a substrate for LV myocardial remodeling in this group of patients. Probably, there is a violation of the contraction and relaxation of the longitudinal fibers of the myocardium in young women with preserved LV EF. We can only guess the direction of further remodeling of the LV myocardium in young women with UCTD.