イソプロテレノール徐放剤の使用経験 めまい症に対する臨床効果とその文献的考察

Abstract

Effects of isoproterenol were clinically studied on 37 patients with vertigo and these effects were assessed two weeks later by subjective and objective parameters. Isoproterenol proved effective for those with a peripheral vertigo, but was less effective for those with a vertigo of a central origin. Of the subjective parameters, vertigo sensation, nausea and/or vomiting, and headache and/or “heavy head feeling” were prominently improved in the peripheral vertigo groups. On the other hand, the effects on tinnitus and shoulder stiffness were limited, and hearing impairment was not improved. Objective parameters such as found in the postural reflex test (Mann's test), stepping test, writing test, spontaneous nystagmus test, positional and positioning nystagmus test, and caloric test were also improved in the peripheral groups. Palpitation which occurred in two patients was transient and slight and disappeared simultaneously with the cessation of the administration.