リン酸Ｌ‐アスコルビルマグネシウムの化粧品への応用

Abstract

The purpose of this study was to evaluate the ability of magnesium ascorbate phosphate in combination with tocopheryl acetate to prevent free radical induced lipid peroxydation in an in vitro biological system, and to develop formulations of various skin care cosmetics containing magnesium ascorbate phosphate.Irradiation by ultraviolet light in the UVB and UVA induces free radical formation, which in turn results in lipid peroxydation. This analysis measured malonyl dialdehyde (MDA), an active end product of lipid peroxydation, levels in the slc-Wister rat model. The MDA levels decreased considerably with increasing concentrations of magnesium ascorbate phosphate in combination with tocopheryl acetate. The addition of 2mM magnesium ascorbate phosphate resulted in a 33% decrease in measured MDA levels from the addition of 0.2mM tocopheryl acetate alone. These results may suggest that magnesium ascorbate phosphate have substantial synergistic effects with tocopheryl acetate in reducing MDA levels.Behavior of magnesium ascorbate phosphate in aqueous media was also investigated. Phase inversion temperature in an emulsion system and clouding point of ethoxylate nonionic surfactant aqueous solutions were lowered by adding magnesium ascorbate phosphate. These tendencies were the same as with the addition of sodium chloride and magnesium chloride.Formulations of various skin care cosmetics were developed by studying effects of magnesium ascorbate phosphate on emulsions and liposomes.