Мікроскопічна будова серця, органів кровотворення та імунногенезу собак за експериментального відтворення парвовірозу

Abstract

A fairly common disease of dogs in Ukraine is parvovirus enteritis, which is extremely common (51.6%) among enteritis of viral etiology and causes significant economic and moral damage to pet owners. Therefore, the need for additional studies to clarify, supplement and summarize data on the pathology of various organs and tissues in parvovirus enteritis in dogs, modern methods of immunoprophylaxis and treatment can significantly reduce morbidity and mortality for this infection. Given the relevance of the topic, the result of our study is the refinement, addition and synthesis of data on the pathomorphology of various organs and tissues of dogs during experimental reproduction of parvovirosis, which will make it possible to explain in more detail the effect of the pathogen on animals with parvovirus enteritis. The article analyzing the results of histological studies presents data on the microscopic structure of the blood-forming organs and the immune defense - the thymus, spleen, lymph nodes and the heart of dogs during experimental infection with their parvovirus enteritis. It has been established that in dogs with experimental to infect of parvovirus enteritis, microscopic changes in the hematopoietic and immune defense organs are recorded. At the same time, the most pronounced changes in the thymus are impaired lymphocyte differentiation processes in thymic lobules, lymph nodes and expansion of blood vessels and swelling of the cortex and medulla, in the spleen, pulp edema and accumulation of red granules and iron-containing pigment grains in the spleen, hemosiderin , the result of the breakdown of a large number of red blood cells. In the myocardium, microscopic changes were manifested by diffuse edema between muscle and connective tissue, granular dystrophy of cardiomyocytes and the presence of intranuclear eosinophilic taurus inclusions. The complex of histological changes in the blood-forming organs and immune defense and the myocardium that we found during experimental reproduction of parvovirosis can be considered a characteristic criterion for the pathomorphological differential diagnosis of parvovirus enteritis in dogs